Effectiveness of sulpiride in adult patients with schizophrenia.

نویسندگان

  • Edward Chia-Cheng Lai
  • Chia-Hsien Chang
  • Yea-Huei Kao Yang
  • Swu-Jane Lin
  • Chia-Yin Lin
چکیده

The objective of this study is to compare the effectiveness among sulpiride, risperidone, olanzapine, and haloperidol by evaluating the persistence of drug use. A retrospective cohort study was conducted by analyzing the National Health Insurance Research Database of Taiwan. Patients with schizophrenia aged 18-65 years and newly prescribed with a single oral antipsychotic medication between years 2003 and 2008 were included. The primary outcome was the persistence of antipsychotic agents by calculating the treatment duration till treatment changed. All defined treatment changes were also analyzed separately, including discontinuation, switching, augmentation, and hospitalization. A total of 1324 eligible patients were included, with an average age of 36 years old and approximately 45% of them were female. The most prevalent antipsychotic use was risperidone (42.1%), followed by sulpiride (36.0%), haloperidol (14.2%), and olanzapine (7.7%). After adjusting for patient demographics, mental illness characteristics, and propensity score, the Cox regression models found that the risk of nonpersistence was significantly higher in patients receiving risperidone (hazard ratio [HR], 1.22; 95% CI, 1.06-1.40), haloperidol (HR, 1.98; 95% CI, 1.63-2.40), and olanzapine (HR, 1.34; 95% CI, 1.07-1.68), as compared with sulpiride, suggesting the effectiveness of sulpiride was better than the other 3 antipsychotics. Therefore, this study would provide strong grounds for a properly conducted randomized controlled trial of the clinical- and cost-effectiveness of sulpiride vs atypical antipsychotics.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Sulpiride: an antipsychotic with selective dopaminergic antagonist properties.

OBJECTIVE To review the pharmacology, pharmacokinetics, clinical investigations, and adverse effects of sulpiride as a treatment for schizophrenia. DATA SOURCES Information was selected from a MEDLINE search of English-language medical literature using "sulpiride" as the search term. Manual searches of pertinent journal article bibliographies also were performed. STUDY SELECTION Clinical in...

متن کامل

P-5: Evaluation of The Effect of Sulpiride As An Atypical Antipsychotic Drug, on The Serum Levels of Prolactin, LH, FSH and Testosterone in Adult Male Mice

Background: Prescription of the atypical antipsychotic drugs like as Sulpiride for the treatment of schizophrenic patients was increased because of their less side effects. This study was aimed to evaluate the effect of sulpiride on hormonal milieu of adult male mice namely their serum level of prolactin and sexual hormones. Materials and Methods: 24 adult male mice were divided in three groups...

متن کامل

P-50: The Effect of Sulpiride on Reproductive System in Female Rats

Background: Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. Sulpiride is effective in the treatment of acute and chronic schizophrenia.Sexual function is multifaceted and is affected in many ways by schizophrenia and the antipsychotic drugs used in its treatment . Sulpiride are associated with elevation of pr...

متن کامل

The Effectiveness of Family Psychological Training on Prevention of Recurrence of Symptoms in Patients with Schizophrenia Spectrum Disorders

Introduction: Schizophrenia spectrum disorders are one of the most common psychiatric disorders, meaning an abnormal mental state that is often described as "loss of contact with reality." Recurrence of symptoms and frequent hospitalizations are characteristics of patients with these disorders. The aim of this study was to determine the effectiveness of family psychoeducation education on the p...

متن کامل

The Effectiveness Of "Open The Doors" Program On Meta-Cognitive Beliefs, Self-Care Activities, And Instrumental Activities Of In Patients With Schizophrenia

Background: Schizophrenia is one of the most disabling mental disorders, in which important functional activities such as independent life, production, and occupational activities, and social interactions of affected patients are damaged. The purpose of this study was to investigate the effectiveness of "Open the Doors" program education on meta-cognitive beliefs, self-care activities, and acti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Schizophrenia bulletin

دوره 39 3  شماره 

صفحات  -

تاریخ انتشار 2013